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This information was found on the Internet under the topic:
Cetyl Myristoleate.
What is Cetyl Myristoleate?
Cetyl Myristoleate is an ester of fatty acid. Fatty acids are
the individual components of oils in the same way that amino
acids are the building blocks of proteins. Polyunsaturated fatty
acids, such as linotenic acid and linolelic acid, are crucial
to life and are called essential fatty acids (EFAs). Research
shows that Cetyl Myristoleate appears to have the same beneficial
characteristics as the EFAs, however, it is stronger and the
benefits are longer lasting.
EFAs are essential to normal cell structure, physiological processes,
body function, and function as components to nerve cells and
cell membranes. EFAs are depleted in chronic inflammatory diseases
and their deficiency are associated with many autoimmune diseases.
EFAs when used over an extended period of time have been shown
to decrease pain, inflammation, and motion limitations of arthritis.
Cetyl Myristoleate offers the same benefits in about a month
instead of extended periods of time... which may be years.
If we take a fatty acid, myristoleic acid, and combine it with
a long-chain alcohol molecule, cetyl alcohol, we have created
an ester of this fatty acid called cetyl myristoleate. Both
of these molecules occur in nature. Cetyl alcohol was first
derived from the oil of the sperm whale, but now is obtained
from palmitic acid (a saturated fatty acid) found in coconut
and palm oils. Myristoleic acid is found in the oil glands of
beavers, the oil of the sperm whale again, in certain vegetables
and nuts. Both of these products were used in the cosmetic industry
because of their ability to act as lubricants. One of the mechanisms
of Cetyl Myristoleate is as a super lubricant (surfactant),
a kind of WD-40 for the joints. A surfactant not only has a
dissolving or thinning action, it also makes other products
easier to absorb.
Concerning the treatment for arthritis, how can one product
address all of the causes of this complex disease?
Cetyl Myristoleate seems to function in three very different
capacities.
Firstly, as mentioned above, it serves as a surfactant and not
only lubricates the involved joints, but also lubricates the
entire body, making muscles glide more smoothly over other muscles,
bursas, and bones and at the same time softens these tissues
making them more pliable. Secondly, it functions as an immune
system modulator. This is the reason it has been found to be
so effective in treating autoimmune diseases such as rheumatoid
arthritis, systemic lupus erythematosus, and multiple sclerosis.
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Thirdly, it functions like
a fatty acid in that it mediates inflammatory processes.
When cooled, Cetyl Myristoleate is a waxy substance and,
at room temperature, has a buttery consistency.
How Was Cetyl Myristoleate Discovered?
Cetyl Myristoleate was discovered and isolated by one
person, working alone, on a quest to find a cure for arthritis.
Harry W. Diehl, while employed by the National Institutes
of Arthritis, Metabolism, and Digestive Diseases, specialized
in sugar chemistry.
He used his chemical knowledge and research instincts
to great advantage, identifying and characterizing over
500 compounds, several of which were patented by the National
Institutes of Health (NIH).
Diehl's interest in discovering a way to help victims
of arthritis began over 40 years ago when his friend and
neighbor, a carpenter, developed severe rheumatoid arthritis.
His condition deteriorated over time until he became disabled.
The neighbor had a family to support, but his arthritis
made that impossible. Diehl is a deeply religious man
whose feelings overwhelmed him as his friend's condition
worsened. Harry thought, "Here I am at the National
Institutes of Health, and I have never seen anything that
was good for curing arthritis."
He decided to establish a laboratory in his home and embark
on a search for something to relieve the pain and disability
of his neighbor and the millions of people who suffer
from arthritis. Unfortunately, he was too late to help
the neighbor, but Diehl's research did lead to the discovery
of Cetyl Myristoleate, which may someday be hailed as
one of the significant nutritional discoveries of the
20th century.
As a researcher, Diehl knew that finding a cure for arthritis
first meant inducing the disease experimentally in research
animals. He started with mice, and quickly realized that
he was unable to induce arthritis in them. Diehl said
he tried every way he could to give those mice arthritis,
but they just would not get it. Then he contacted a researcher
in California who wrote back to him, "If you or anyone
else can give mice arthritis, I want to know about it,
because mice are 100% immune to arthritis." |
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At that moment, Diehl's research
instincts told him that what he wanted was already somewhere
in those mice. It was a long, tedious job, working on
his own in his spare time, but Diehl finally found the
factor --Cetyl Myristoleate-- that protected mice from
arthritis.
As Diehl said, "It didn't come on a silver platter
to me, but after years of chemical sleuthing and just
old fashioned chemical cooking, I found it!"
On thin layer chromatography of methylene chloride extract
from macerated mice, Diehl noticed a mysterious compound,
which was subsequently identified as Cetyl Myristoleate.
As Diehl was to prove, Cetyl Myristoleate circulates in
the blood of mice and makes them immune to arthritis.
Cetyl Myristoleate is now known to be found in sperm whale
oil and a small gland in the beaver. At this time no other
sources in nature are known to contain Cetyl Myristoleate.
While the first amount of Cetyl Myristoleate for experimentation
was extracted from mice, Diehl quickly developed a method
for making Cetyl Myristoleate in the lab by esterification
of myristoleic acid.
What is the Chemical Make Up of Cetyl Myristoleate? A
New Compound?
Cetyl Myristoleate, an oil, is the hexadecyl ester of
the unsaturated fatty acid cis-9 tetradecenoic acid. The
common name for the acid is myristoleic acid. Myristoleic
acid is found commonly in fish oils, whale oils, dairy
butter, and kombo butter. The chemical formula for Cetyl
Myristoleate is (Z)-ROCO(CH2)7CH=CH(CH2)3CH3. Cetyl Myristoleate
was unrecorded in chemical literature until Diehl's discovery
was reported. The current Merck Index of Chemicals does
not list Cetyl Myristoleate. A search of Chemical Abstracts
lists Diehl's method of extracting Cetyl Myristoleate
from mice but contains no reference to Cetyl Myristoleate
prior to his 1977 patent.
How Did Harry Diehl Test CMO?
To test his theory that mice are immune to arthritis because
of Cetyl Myristoleate, Diehl began to experiment on laboratory
rats. This research was reported in an article written
in conjunction with one of his colleagues at NIH in the
Journal of Pharmaceutical Sciences. In summary, this paper
reports that ten normal mice were injected in the tail
with Freund's Adjuvant (heat-killed desiccated Mycobacterium
butyricum) to which rats and certain other rodents are
susceptible. In a period of 10-20 days, no swelling was
detected as determined by comparison of the measurements
of paws at the time of injection. |
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Then, one group of rats was
injected with Cetyl Myristoleate, and 48 hours later,
they were given Freund's adjuvant. Another control group
of rats received Freund's adjuvant only. Both groups of
rats were observed for a total of 58 days with respect
to weight change, hind and front leg swelling, and general
well being. All rats receiving only Freund's adjuvant
developed severe swelling of the front and hind legs,
lagged in weight gain, and was lethargic and morbid. Those
receiving Cetyl Myristoleate before receiving Freund's
adjuvant grew an average of 5.7 times as much as the control
group and had little if any evidence of swelling or other
symptoms of polyarthritis.
The authors concluded that it was apparent that Cetyl
Myristoleate gave virtually complete protection against
adjuvant-induced arthritis in rats.
Did Harry Diehl Patent CMO?
Diehl patented his discovery in 1977, receiving a use
patent for rheumatoid arthritis. Diehl had made a major
nutritional discovery. He then sought pharmaceutical companies
to conduct human trials with Cetyl Myristoleate, but none
were interested in his discovery. Perhaps the lack of
interest was because Cetyl Myristoleate was a natural
substance and could not be granted a product patent, or
maybe because drug companies know they will have to run
through 25,000 to 35,000 substances before they find one
that makes the market. Diehl had made a major nutritional
discovery, and no one was interested! Being a scientist,
not a marketing expert, Diehl let his discovery lay dormant
for about 15 years.
Cetyl Myristoleate Cures Diehl's Arthritis
As Diehl got older, he began to experience some osteoarthritis
in his hand, his knees, and his heels. His family physician
tried the usual regimen of coritsone and non-steroidal
anti-inflammatory drugs without much effect on the course
of the disease. Finally his physician told Harry he could
not have any more cortisone. "So," Diehl said
"I thought about my discovery, and I decided to make
a batch and use it on myself." He did, and successfully
cured himself of his osteoarthritis.
Many of his family members and friends became aware of
the relief Diehl found from his discovery, and they wanted
to try it too. Time after time, people with both rheumatoid
arthritis and osteoarthritis received astounding relief
with Cetyl Myristoleate. Before long, family members and
friends grew into customers, and Cetyl Myristoleate appeared
on the market as a dietary supplement. |
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Patented Again for Osteoarthritis
As more people tried Harry's Cetyl Myristoleate and either
eliminated their arthritis or received substantial long-term
relief, they told others and demand for the product grew.
At this point Harry decided to file for a patent for using
CM for osteoarthritis. He received the patent in 1996.
The patent was assigned to EHP Products, the company owned
and led by his daughter, Elaine Diehl Parrish. EHP Products
has established a licensing program under the patent and
only companies licensed under this patent will be authorized
to use the trademark name MyristinTM. This name is an
assurance that the product is the true Cetyl Myristoleate
discovered by Harry Diehl, is pure, and of the highest
quality available. (Vaughn Marketing is a company licensed
under this patent.)
Many of his family members and friends became aware of
the relief Diehl found from his discovery, and they wanted
to try it too. Time after time, people with both rheumatoid
arthritis and osteoarthritis received astounding relief
with Cetyl Myristoleate. Before long, family members and
friends grew into customers, and Cetyl Myristoleate appeared
on the market as a dietary supplement.
What Happens When Humans Take CMO?
Both osteoarthritis and rheumatoid arthritis sufferers
report striking improvements with Cetyl Myristoleate.
Numerous private correspondence describe decreased stiffness
and pain and increased flexibility and range of motion
with Cetyl Myristoleate. Swelling and redness is reduced
in rheumatoid arthritis.
Writers describe other health benefits, including positive
effects of Cetyl Myristoleate on emphysema, hepatitis,
hypertension, diabetes, eczema, psoriasis, colds, allergies,
low back pain, headaches and more. These reported improvements
in general health status are not surprising since each
of these conditions could be associated with deficiency
in the balance of Essential Fatty Acids.
One writer, Douglas Hunt, M.D., in his book Boom You're
Well With Cetyl Myristoleate calls Cetyl Myristoleate
"A New Natural Anti-Aging Disease Fighter".
Like everything else, Cetyl Myristoleate does not work
100% of the time. Failure to work can be associated with
failure to follow the dietary recommendations; failure
to use lipase in conjunction with each capsule of Cetyl
Myristoleate; failure to take sufficient amounts of Cetyl
Myristoleate; failure of the liver to uptake and respond
to the Cetyl Myristoleate; and misdiagnosis in which the
condition is not really an arthritis-type condition. |
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How Much & How Long Does
One Have To Take CMO To Feel Its Effects?
Eight - 12 grams per Mr. Diehl. Some will usually respond
in the first 7 - 21 days.
Cetyl Myristoleate is taken in a one-month course. A total
dose of 12 - 15 grams appears to be indicated. This is
usually enough for most people, but for osteoarthritic
sufferers, the dose appears to be related to the number
of areas in which cartilage has worn away. For example,
a patient with osteoarthritis of the knees could expect
10 to 15 grams to sufficient in most cases, while a patient
with osteoarthritis of 5 or 6 spinal discs, both hips
and both knees may require an additional 5 to 10 grams,
or even a full second course.
Does CMO Have Side Effects?
No negative ones have been observed or noted.
Rather than having negative side effects, CMO appears
to have many positive ones! According to many researchers
and scientists, doctors using CMO in their practices,
along with writers of articles and authors of books on
Cetyl Myristoleate, CMO works on many other autoimmune
diseases and even has anti-aging properties!
With the hundreds of people who have taken Cetyl Myristoleate
there have been no confirmed reports of adverse side effects.
In common with fish oils, it may produce some mild burping
in some people which passes within an hour. There have
been no reported interactions with other medications or
natural substances.
Toxicity studies have been performed on Cetyl Myristoleate
and the lack of toxicity is evident. Test results deemed
Cetyl Myristoleate a non-toxic material in accordance
with Federal regulations. Mega-doses were given to test
animals with no ill effects. Necropsy of test animals
showed no ill effects on the internal organs. The LD50
of Cetyl Myristoleate was not established, but it can
be presumed to far exceed 10 grams per kilogram of body
weight.
While teratogenicity of Cetyl Myristoleate is probably
the same as for EFA's, as a safety matter, Cetyl Myristoleate
should not be used by pregnant or lactating women until
studies of Cetyl Myristoleate effects on fetuses and infants
have been done. As with any substance being added to the
diet of anyone with asthma or a history of severe allergies,
the direct supervision of a health care professional is
recommended. |
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